3-CHYMOTRYPSIN-LIKE PROTEASE (3CLPRO) OF SARS-COV-2: VALIDATION AS A MOLECULAR TARGET, PROPOSAL OF A NOVEL CATALYTIC MECHANISM, AND INHIBITORS IN PRECLINICAL AND CLINICAL TRIALS

Proteases represent common targets in combating infectious diseases, including COVID-19.The 3-chymotrypsin-like protease (3CLpro) is a validated molecular target for COVID-19, and it is key for developing potent and selective inhibitors for inhibiting viral replication of SARS-CoV-2.In this review, we discuss structural relationships and diverse su

Fast neutron computed tomography (FNCT) generally needs a longer measurement time because of low source strength and low detection efficiency.In order to reduce measurement time, methods of reducing single measurement time and the numbers of projection are employed, but, the two reductions lead to high statistics noise projections and sparse sampli

Abstract The purpose of this research Nail Strengthening Products is to provide an in-depth analysis of the commodification, authenticity, and sustainability of culinary legacy as an instance of intangible cultural legacy, as well as how to subsequently compete with excellence and sustainability in the midst of a modern, global era of business with